[Pathogenesis of paramphistomiasis in sheep]

Area of Science:

• Veterinary Parasitology
• Animal Pathology

Background:

• Paramphistomum infections are significant helminthic diseases in ruminants.
• Understanding the pathogenesis is crucial for effective disease management in livestock.

Purpose of the Study:

• To investigate the pathogenesis of Paramphistomum infection in weaned lambs.
• To evaluate hematological, biochemical, and histopathological changes following experimental infection.

Main Methods:

• 58 weaned lambs were experimentally infected with varying doses of Paramphistomum adolescaria.
• Hematological parameters (protein, hemoglobin, blood counts, hematocrit) and serum biochemistry (Ca, P, enzymes) were monitored.
• Histopathological examination of organs (liver, spleen, kidneys, adrenals, lymph nodes, duodenum, rumen) was performed.

Main Results:

• Significant alterations in blood picture and protein fractions, notably a near doubling of gamma-globulins by day 90.
• Microscopic findings included degenerative changes in parenchymal organs, duodenum, and rumen.
• Evidence of reticulo-histiocytic proliferation, eosinophilic infiltration, and necrotic foci in the rumen.

Conclusions:

• Paramphistomum infection induces notable reconstructive and degenerative changes in lambs.
• Hematological and histopathological findings highlight the systemic impact and inflammatory responses caused by the parasite.