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Using Eggs from Schistosoma mansoni as an In vivo Model of Helminth-induced Lung Inflammation
Published on: June 5, 2012
[Pathogenesis of paramphistomiasis in sheep]
Veterinarno-Meditsinski Nauki
|January 1, 1985
Summary
Paramphistomum infection in lambs causes significant blood and protein changes, including increased gamma-globulins. Histopathology reveals organ degeneration and inflammatory responses in the rumen and duodenum.
Area of Science:
- Veterinary Parasitology
- Animal Pathology
Background:
- Paramphistomum infections are significant helminthic diseases in ruminants.
- Understanding the pathogenesis is crucial for effective disease management in livestock.
Purpose of the Study:
- To investigate the pathogenesis of Paramphistomum infection in weaned lambs.
- To evaluate hematological, biochemical, and histopathological changes following experimental infection.
Main Methods:
- 58 weaned lambs were experimentally infected with varying doses of Paramphistomum adolescaria.
- Hematological parameters (protein, hemoglobin, blood counts, hematocrit) and serum biochemistry (Ca, P, enzymes) were monitored.
- Histopathological examination of organs (liver, spleen, kidneys, adrenals, lymph nodes, duodenum, rumen) was performed.
Main Results:
- Significant alterations in blood picture and protein fractions, notably a near doubling of gamma-globulins by day 90.
- Microscopic findings included degenerative changes in parenchymal organs, duodenum, and rumen.
- Evidence of reticulo-histiocytic proliferation, eosinophilic infiltration, and necrotic foci in the rumen.
Conclusions:
- Paramphistomum infection induces notable reconstructive and degenerative changes in lambs.
- Hematological and histopathological findings highlight the systemic impact and inflammatory responses caused by the parasite.
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