Association between the triglyceride-glucose index and mortality in the asthma population
Pan Jiang1, Hongyu Lu2, Yichun Jiang3
1Department of Stomatology, Shenzhen Guangming District People's Hospital, Shenzhen, Guangdong, China.
Objective:
To explore the relationship between the triglyceride-glucose (TyG) index and mortality in individuals with asthma, given the inconclusive evidence linking metabolic dysfunction to asthma outcomes.
Research Design And Methods:
We analyzed data from 5985 adults with asthma from the National Health and Nutrition Examination Survey (NHANES) 2001-2018. We used multivariable weighted Cox regression, smoothing curve fitting, survival curve analysis, and subgroup analysis to assess the correlation between the TyG index and survival rates.
Results:
A higher TyG index significantly correlated with increased all-cause mortality in asthmatics. Adjusted hazard ratios (HR) for higher TyG index categories (compared to TyG <8) were: 1.69 (95 % CI: 1.28, 2.24, p < 0.001) for 8 ≤ TyG <9, 2.04 (95 % CI: 1.51, 2.76, p < 0.001) for 9 ≤ TyG <10, and 2.94 (95 % CI: 2.03, 4.28, p < 0.001) for TyG ≥10. Restricted cubic spline analysis revealed a nonlinear relationship between the TyG score and mortality. Kaplan-Meier curves showed higher TyG indexes associated with greater mortality risk.
Conclusions:
The TyG index is a significant predictor of mortality in asthma patients, highlighting its potential for risk stratification. Incorporating the TyG index into clinical assessments could improve monitoring and management. Future research should investigate interventions targeting the TyG index to enhance survival and quality of life in asthma patients.
More Related Videos
08:30Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
Published on: March 15, 2018
04:54Using a Combination of Indirect Calorimetry, Infrared Thermography, and Blood Glucose Levels to Measure Brown Adipose Tissue Thermogenesis in Humans
Published on: June 2, 2023
Related Concept Videos
Hypoglycemia and Glucagon
Asthma-III: Symptoms and Complications
Classification of Asthma
Diabetes: Symptoms, Diagnosis, and Complications
Oral Hypoglycemic Agents: Biguanides and Glitazones
Overview of Carbohydrate Metabolism
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Asthma-I: Introduction
