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Updated: May 28, 2025
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Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance
Published on: February 14, 2025
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Factors influencing osteoradionecrosis progression during hyperbaric oxygen therapy: A case study
Sameh Mezri1,2, Chaima Zitouni1,2, Khadija Bahrini1,3
1University of Tunis El Manar, Rommana, Tunis, 1068, Tunisia.
F1000Research
|February 11, 2025
Summary
Hyperbaric oxygen therapy (HBOT) can help manage osteoradionecrosis (ORN) of the head and neck. More HBOT sessions and timely dental care are key factors for better ORN outcomes.
Area of Science:
- Oncology
- Radiotherapy
- Otolaryngology
Background:
- Osteoradionecrosis (ORN) is a severe complication following radiotherapy.
- Hyperbaric oxygen therapy (HBOT) is a treatment option for ORN.
Purpose of the Study:
- To evaluate HBOT's role in managing head and neck ORN.
- To identify predictive factors for ORN evolution after HBOT.
Main Methods:
- Retrospective study of 46 patients with head and neck ORN treated with HBOT.
- Statistical analysis to identify factors influencing ORN progression.
Main Results:
- ORN commonly affected the mandible.
- ORN regressed in 33%, stabilized in 45%, and worsened in 22% of patients.
- Factors like high blood pressure, tumor size, radiation dose, and delayed dental care were associated with ORN progression. More HBOT sessions improved outcomes.
Conclusions:
- HBOT is a viable treatment for head and neck ORN.
- Predictive factors for ORN evolution include treatment timing and HBOT duration.
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