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Related Experiment Video

Updated: May 6, 2026

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Case Report: Atypical post-COVID Cogan's syndrome.

Sameh Mezri1,2, Chaima Zitouni1,2, Wafa Sleimi1,2

  • 1University of Tunis El-Manar, Tunis, Tunisia.

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|February 11, 2025
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Summary

This case report details a rare instance of Cogan's syndrome, an autoimmune disorder, presenting with neurological complications after COVID-19 infection. The patient experienced ocular inflammation, hearing loss, and meningitis, highlighting atypical disease progression.

Keywords:
COVID-19Case reportCogan SyndromeHearing LossMeningitis

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Area of Science:

  • Ophthalmology
  • Neurology
  • Rheumatology

Background:

  • Cogan's syndrome is a rare autoimmune disorder featuring ocular inflammation, vestibulocochlear dysfunction, and systemic vasculitis.
  • Early diagnosis and treatment are crucial for managing this condition and preventing severe complications.

Observation:

  • A 28-year-old female developed keratitis, uveitis, and retinal vasculitis one month post-COVID-19 infection.
  • She subsequently experienced vertigo, tinnitus, and sudden hearing loss, consistent with Cogan's disease.
  • Neurological involvement manifested as lymphocytic meningitis and elevated intracranial pressure.

Findings:

  • Corticosteroid therapy led to ocular symptom regression but not hearing recovery, resulting in complete deafness.
  • The patient's neurological symptoms improved with treatment.
  • Cochlear implants were successfully implemented.

Implications:

  • This case highlights an atypical presentation of Cogan's syndrome with neurological sequelae following COVID-19.
  • It underscores the importance of considering Cogan's syndrome in patients with autoimmune manifestations post-viral infections.
  • Further research is needed to understand the link between COVID-19 and Cogan's syndrome, especially concerning neurological involvement.