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Updated: May 7, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
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Case report: Dupilumab-induced linear psoriasis: a rare presentation
Wen Sun1, Kexin Wang1, Yuekang Ren1
1The First Clinical Medical College, Shanxi Medical University, Taiyuan, Shanxi, China.
Frontiers in Medicine
|February 11, 2025
Summary
Dupilumab treatment for prurigo nodularis can unexpectedly trigger linear psoriasis. This suggests dupilumab may cause immune shifts and alter gene expression, impacting skin conditions.
Area of Science:
- Immunodermatology
- Molecular biology
- Genetics
Background:
- Prurigo nodularis is a chronic inflammatory skin condition.
- Dupilumab is an interleukin-4 (IL-4) and interleukin-13 (IL-13) inhibitor used for inflammatory diseases.
- The therapeutic mechanisms of dupilumab are primarily linked to modulating Th2-mediated inflammation.
Observation:
- A 42-year-old male patient with prurigo nodularis was treated with dupilumab.
- The patient subsequently developed a distinct presentation of linear psoriasis.
- This co-occurrence was unexpected given the known mechanisms of dupilumab.
Findings:
- Dupilumab treatment induced a shift in the immune response.
- Evidence suggests chimeric gene expression occurred in the affected skin.
- The development of linear psoriasis indicates a complex interplay between the drug, immune system, and genetic factors.
Implications:
- Dupilumab may have broader immunomodulatory effects beyond Th2 pathways.
- Understanding these immune shifts is crucial for managing potential side effects.
- Further research is needed to elucidate the mechanisms of dupilumab-induced psoriasis and chimeric gene expression.
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