Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hormone therapy and affect.

L Dennerstein, G D Burrows, G J Hyman

    Maturitas
    |June 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The teat skin microbiota of organic primiparous dairy cows is dynamic during the transition period.

    Preventive veterinary medicine·2025
    Same author

    Exploring associations between the teat apex metagenome and <i>Staphylococcus aureus</i> intramammary infections in primiparous cows under organic directives.

    Applied and environmental microbiology·2024
    Same author

    Adherence to the Mediterranean Diet Is not Related to Beta-Amyloid Deposition: Data from the Women's Healthy Ageing Project.

    The journal of prevention of Alzheimer's disease·2018
    Same author

    Linking routinely collected social work, education and health data to enable monitoring of the health and health care of school-aged children in state care ('looked after children') in Scotland: a national demonstration project.

    Public health·2017
    Same author

    New insights for identification of doping with recombinant human erythropoietin micro-doses after high hydration.

    Drug testing and analysis·2016
    Same author

    Ductal Plate Malformation in the Liver of Boxer Dogs: Clinical and Histological Features.

    Veterinary pathology·2016
    Same journal

    Intrinsic capacity and the trajectory of ischemic heart disease and its complications: the mediating role of insulin resistance indices.

    Maturitas·2026
    Same journal

    Mobility limitation trajectories and longitudinal changes in delayed recall in midlife and later life: A multicohort study.

    Maturitas·2026
    Same journal

    Digital twins in menopause: a roadmap for integrating endocrine dynamics, multisystem physiology, and precision medicine.

    Maturitas·2026
    Same journal

    Testosterone therapy in women: Keeping pace with the evidence.

    Maturitas·2026
    Same journal

    Diagnosis and management of androgen excess presenting after menopause.

    Maturitas·2026
    Same journal

    Domain-specific severity of menopausal symptoms and emotional eating in midlife women.

    Maturitas·2026
    See all related articles

    Hormone therapy, specifically ethinyl estradiol, improved mood and reduced anxiety in women post-hysterectomy. Levonorgestrel showed initial drawbacks but improved over time, suggesting hormone therapy can benefit menopausal affect.

    Area of Science:

    • Gynecology
    • Endocrinology
    • Psychiatry

    Background:

    • Post-hysterectomy and bilateral oophorectomy can lead to significant hormonal changes affecting mood and well-being.
    • Hormone therapy is often considered for managing symptoms in women experiencing surgical menopause.

    Purpose of the Study:

    • To investigate the effects of different hormone therapies on the emotional state (affect) of women after hysterectomy and bilateral oophorectomy.
    • To compare the efficacy of ethinyl estradiol, levonorgestrel, a combination therapy (Nordial), and placebo in managing affect.

    Main Methods:

    • A double-blind, crossover trial involving 49 women.
    • Participants received 3-month treatments of ethinyl estradiol (50 mcg/day), levonorgestrel (250 mcg/day), Nordial, and placebo.
    • Affect was assessed using the Hamilton Depression Rating Scale, verbal reports, and visual analogue scales.
    Keywords:
    BehaviorCentral Nervous System EffectsContraceptionContraceptive AgentsContraceptive Agents, EstrogenContraceptive Agents, FemaleDepression--analysisDiseasesEthinyl EstradiolFamily PlanningMental DisordersPopulation CharacteristicsPsychological Factors

    Related Experiment Videos

    Main Results:

    • Ethinyl estradiol demonstrated a beneficial impact on mood, reducing anxiety, irritability, and insomnia, as indicated by Hamilton scores.
    • The positive effect of hormones on Hamilton scores was partly, but not entirely, attributed to the reduction of hot flushes.
    • Levonorgestrel initially showed less favorable effects, but these improved by the end of the third treatment month.

    Conclusions:

    • Ethinyl estradiol appears to be effective in improving affect and reducing anxiety symptoms in women post-oophorectomy.
    • Levonorgestrel's effects on mood warrant further investigation, considering the observed initial drawbacks and later improvement.
    • Visual analogue scales may have limited validity for assessing affect in individuals without significant psychiatric conditions.