Chromones from stems of Harrisonia perforata

Four new chromones, named harforamone A (1), harforamone B (2), harforamone C (3), and harforamone D (4), together with six known compounds (5-10) were isolated from the dichloromethane extract of the stems of Harrisonia perforata. The chemical structures of four new compounds were elucidated by spectroscopic analysis, including 1D, 2D NMR and HRESIMS data. The known compounds were identified by comparing their spectroscopic data with the previously reported data. Compounds 7 and 8 were isolated for the first time from the Rutaceae family. The in vitro cytotoxic activity against six human cancer cell lines of the tested compounds was evaluated, but none of them showed any significant activity; only perforamone C (5) showed moderate cytotoxicity against cervical cancer cell line (HeLa).