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Transcorneal Electrical Stimulation Modulates Visual Pathway Function in Mice.

Valerio Castoldi¹, Elena Rossi¹, Silvia Marenna¹

¹Experimental Neurophysiology Unit, Institute of Experimental Neurology (INSPE) - IRCCS San Raffaele Scientific Institute, Milan, Italy.

Journal of Neuroscience Research

|February 11, 2025

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Transcorneal Electrical Stimulation (TES) enhanced visual pathway activity in mice. This electrical eye stimulation significantly increased visual evoked potential and electroretinogram amplitudes, suggesting potential for vision restoration therapies.

Area of Science:

Neuroscience
Ophthalmology
Biomedical Engineering

Background:

Electrical stimulation of the eye shows potential for vision preservation and restoration.
Understanding the neuromodulatory effects of electrical currents on visual function is crucial.

Purpose of the Study:

To investigate the neuromodulatory effects of Transcorneal Electrical Stimulation (TES) on the visual pathway.
To evaluate the impact of TES on neuronal activity from the retina to the cerebral cortex.

Main Methods:

Transcorneal Electrical Stimulation (TES) was applied to anesthetized C57BL/6 mice (both female and male).
Visual evoked potentials (VEP) and electroretinograms (ERG) were recorded at baseline, immediately after, and 10 minutes after TES or sham stimulation.

Keywords:

electroretinogram neuromodulation optic nerve retina visual evoked potential

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Main Results:

TES significantly increased the amplitude of both VEP and ERG.
This amplitude increase persisted for at least 10 minutes post-stimulation.
No significant changes were observed in the sham stimulation group.

Conclusions:

Transcorneal Electrical Stimulation (TES) enhances neuronal excitability within the visual pathway.
TES may offer a therapeutic approach to ameliorate visual system function in various diseases.