Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Canonical Wnt Signaling Pathway

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pangenome-based structural variant imputation enables large-scale genotype-phenotype studies in dairy cattle.

Nature communications·2026

Same author

Heritability Patterns of Protein-Coding Genes Expression: Insights From the Pig Genotype-Tissue Expression Project.

Animal genetics·2026

Same author

An Expectation and Maximization Algorithm for Multivariate Genome-wide Association Studies (EMmvGWAS).

Genetics·2026

Same author

Integrated multi-omics profiling identifies genetic loci of African swine fever resistance in pigs.

GigaScience·2026

Same author

Cross-species comparison of amniote single-cell transcriptomes reveals evolutionary conservation and divergence in the chicken immune system.

Nature communications·2026

Same author

Cross-Breed Few-Shot Learning for Pig Detection via Improved YOLOv7 and CycleGAN-Based Sample Generation.

Biology·2026

Same journal

Single-cell RNA Sequencing Reveals A Tumor-Promoting Role of EGR1+CD4+ T Cells in Papillary Thyroid Cancer.

Genomics, proteomics & bioinformatics·2026

Same journal

Long-read Sequencing: from Complete Molecules to Context-resolved Biology.

Genomics, proteomics & bioinformatics·2026

Same journal

A Cattle BodyMap of Transcriptome across 52 Tissues and 3 Developmental Stages Reveals New Genetic Insights into Beef Production Traits.

Genomics, proteomics & bioinformatics·2026

Same journal

Real-time Targeted Enrichment in Single-cell Long-read Sequencing.

Genomics, proteomics & bioinformatics·2026

Same journal

Decoding RNA N6-Methyladenosine Methylome of Wheat Using Machine Learning and Nanopore Direct RNA Sequencing.

Genomics, proteomics & bioinformatics·2026

Same journal

Tranquillyzer: A Neural Network Framework for Long-read Annotation and Demultiplexing.

Genomics, proteomics & bioinformatics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 28, 2025

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

FarmGTEx TWAS-server: An Interactive Web Server for Customized TWAS Analysis.

Zhenyang Zhang¹, Zitao Chen¹, Jinyan Teng²

¹Department of Animal Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.

Genomics, Proteomics & Bioinformatics

|February 11, 2025

Summary

This summary is machine-generated.

The FarmGTEx TWAS-server simplifies transcriptome-wide association studies (TWAS) across species and tissues. It links genetic variations to traits, revealing shared genetic bases between pig and human characteristics.

Keywords:

Cross species Farm animal Gene expression Transcriptome-wide association study Web server

More Related Videos

Author Spotlight: Introducing the Tile/SED/Array Interface for Rapid Field of View Positioning in Tissue Imaging

Author Spotlight: Introducing the Tile/SED/Array Interface for Rapid Field of View Positioning in Tissue Imaging

Published on: September 15, 2023

A Web Tool for Generating High Quality Machine-readable Biological Pathways

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

Related Experiment Videos

Last Updated: May 28, 2025

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

Author Spotlight: Introducing the Tile/SED/Array Interface for Rapid Field of View Positioning in Tissue Imaging

Author Spotlight: Introducing the Tile/SED/Array Interface for Rapid Field of View Positioning in Tissue Imaging

Published on: September 15, 2023

A Web Tool for Generating High Quality Machine-readable Biological Pathways

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

Area of Science:

Genomics
Bioinformatics
Comparative Genomics

Background:

Transcriptome-wide association study (TWAS) is crucial for linking genetic loci to complex traits.
Existing TWAS pipelines are complex, hindering cross-species genetic studies.
A need exists for user-friendly, multispecies platforms for TWAS analysis.

Purpose of the Study:

To introduce the Farm Animal Genotype-Tissue Expression (FarmGTEx) TWAS-server, a multispecies platform.
To streamline TWAS analyses across different tissues and species.
To facilitate the translation of genetic findings between species.

Main Methods:

Developed an interactive TWAS-server integrating human, pig, and cattle gene expression data.
Incorporated genotype-based gene expression prediction and GWAS summary statistics imputation.
Enabled customizable TWAS analysis, functional annotation, and visualization.

Main Results:

The server provides prediction models for thousands of genes across species and tissues.
Identified 479,203 human, 1208 cattle, and 657 pig tissue-gene-trait associations.
Validated ABCD4 gene association with pig teat numbers and found shared genetic links between pig backfat and human traits (e.g., BMI).

Conclusions:

The FarmGTEx TWAS-server offers a comprehensive and accessible resource for cross-species TWAS.
The platform facilitates the discovery of conserved genetic mechanisms underlying traits.
Future expansion will include more species, enhancing comparative genetic research.