Related Experiment Video
Updated: May 28, 2025
Author Spotlight: Unraveling the Molecular Mechanisms in PCO and Fibrosis Following Cataract Surgery
Published on: December 1, 2023
PRESUMED MITOMYCIN C-INDUCED RETINAL TOXICITY AFTER COMBINED CATARACT AND XEN GEL STENT SURGERY
Jared J Tuttle1, Shannon D Scarboro2, John C Fitzpatrick2
1Joe R. and Teresa Lozano Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Purpose:
To describe a case of presumed mitomycin C-induced retinal toxicity after combined cataract and XEN gel stent surgery.
Methods:
Observational case report.
Results:
A 66-year-old man presents with progressive vision loss (20/25 baseline to light-perception) after combined cataract and XEN gel stent surgery in the left eye. The patient received 0.15 mL of 0.4 mg/mL of mitomycin C via intratenon injection during the surgery. The patient reported severe eye pain after surgery, which gradually resolved over time. Upon examination at postoperative day 41, vessel attenuation, sclerotic vessels, and optic nerve pallor are observed without any retinal hemorrhaging. At postoperative day 55, visual acuity remains at light-perception with a flatline electroretinogram. Outcomes remain consistent at postoperative day 125.
Conclusion:
Care should be taken to avoid intraocular mitomycin C, especially when administered via intratenon injection during combined cataract and XEN gel stent surgery.
More Related Videos
11:20Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
Published on: June 14, 2021
11:03Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy
Published on: January 22, 2018