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Updated: Apr 30, 2026

Fiber-optic Implantation for Chronic Optogenetic Stimulation of Brain Tissue
Published on: October 29, 2012
Hypoglossal nerve stimulation with Inspire: An operative technique
Thomas Heineman1, Hirotaka Hara2, Seiichi Nakata3
1Department of Otolaryngology/Head and Neck Surgery, Physicians' Clinic of Iowa, Cedar Rapids, Iowa, USA.
Objective:
Obstructive sleep apnea is a chronic medical condition with a significant prevalence in Japan, estimated to be up to 22.3 % of the male working age population with moderate to severe OSA. Hypoglossal nerve stimulation (HNS) is now an established surgical treatment for obstructive sleep apnea. The surgical technique of the Inspire device has not been published in Japan.
Methods:
This study involves combining existing best practice surgical techniques for hypoglossal stimulation implantation with the authors' unique experiences.
Results:
Surgical placement of the Inspire device is a safe and standardized operation. The surgery involves four principal steps: placement of the stimulation lead, placement of the sensing lead, tunneling of the stimulation lead with connection to the implantable pulse generator (IPG), and intraoperative functional testing. There is a standardized technique for these procedures which is discussed in detail. We also discuss known risks to the procedure.
Conclusion:
Hypoglossal nerve stimulation with Inspire is a paradigm shift in the surgical treatment of obstructive sleep apnea. HNS is a surgery that can be readily learned and incorporated into a head and neck surgery practice with familiar technique and anatomy to other procedures within an otolaryngologists' repertoire. A consistent surgical approach can maximize outcomes, reduce complications, and accelerate operative time.
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