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Updated: May 28, 2025
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Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
Published on: July 28, 2010
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Immunosensitivity cuts across mismatch repair status in colorectal cancer
Allyson Moraig Peddle1, Gertjan Rasschaert1, Sabine Tejpar1
1Department of Oncology, KU Leuven, Leuven, Belgium.
Cancer Cell
|February 11, 2025
Abstract:
In this issue of Cancer Cell, Acha-Sagredo et al. reveal an interferon-high immunophenotype in colorectal cancer that predicts responsiveness to immune checkpoint inhibitors across both mismatch repair-deficient and mismatch repair-proficient subtypes. They identify CD74 as a biomarker and establish the importance of epithelial interferon levels in regulating immune responses.
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