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Correlation Between miR-27a-3p Polymorphisms and Peri-Implantitis Susceptibility: A Case-Control Study.
1Department of Stomatology, Dongying People's Hospital, Dongying, China.
International Dental Journal
|February 11, 2025
Summary
The miR-27a-3p rs895819 polymorphism is linked to increased peri-implantitis risk. This genetic variant correlates with lower miR-27a-3p levels and higher inflammatory markers in patients.
Area of Science:
- Genetics and Molecular Biology
- Oral and Maxillofacial Surgery
- Immunology
Background:
- Peri-implantitis (PI) is an inflammatory condition affecting tissues around dental implants.
- Bone metabolism alterations in PI may be influenced by microRNA-27a-3p (miR-27a-3p).
Purpose of the Study:
- Investigate the association between the miR-27a-3p rs895819 polymorphism and PI susceptibility.
- Determine the effects and mechanisms of this polymorphism on inflammatory factors in PI.
Main Methods:
- Assessed miR-27a-3p levels via RT-PCR.
- Genotyped rs895819 using RFLP.
- Measured RUNX1, CRP, and IL-6 concentrations with ELISA.
- Identified target genes using bioinformatics databases and Venn diagrams.
- Performed functional enrichment analysis (GO, KEGG, PPI).
Main Results:
- Underexpression of miR-27a-3p was observed in PI patients.
- The GG genotype and G allele of rs895819 were significantly associated with increased PI susceptibility.
- PI patients with the GG genotype showed decreased miR-27a-3p and elevated RUNX1, CRP, IL-6, and WBC levels.
Conclusions:
- The miR-27a-3p rs895819 polymorphism is a significant risk predictor for peri-implantitis.
- This variant is linked to reduced miR-27a-3p expression and increased RUNX1 and inflammatory factor levels in PI patients.
