Progress in multi-omics studies of osteoarthritis

Area of Science:

• Biomedical Research
• Genomics
• Proteomics

Background:

• Osteoarthritis (OA) is a widespread degenerative joint disease causing pain and disability.
• Aging populations are experiencing an increasing prevalence of OA globally.
• Omics technologies provide comprehensive insights into complex diseases like OA.

Purpose of the Study:

• To systematically review the application and achievements of omics technologies in osteoarthritis research.
• To identify novel therapeutic targets and biomarkers for OA diagnosis and treatment.
• To explore the potential of spatial omics in understanding OA mechanisms and developing therapies.

Main Methods:

• Systematic literature analysis of omics studies in OA.
• Scouring databases such as PubMed for relevant research.
• Summarizing recent advancements and future directions in omics-based OA research.

Main Results:

• Omics technologies have uncovered disease-specific alterations in OA across multiple molecular levels.
• Studies have identified potential new therapeutic targets and biomarkers for OA.
• Spatial omics shows promise for unraveling OA's molecular intricacies.

Conclusions:

• Omics technologies are crucial for advancing osteoarthritis research.
• This review provides a foundation for future OA studies and therapeutic development.
• Continued investigation using omics approaches is vital for improved OA understanding and treatment.