Related Experiment Video
Updated: May 28, 2025

A Guide to Generating and Using hiPSC Derived NPCs for the Study of Neurological Diseases
Published on: February 21, 2015
Human Induced Pluripotent Stem Cells: Directed Differentiation Methods and Applications in Brain Diseases
Yu Wang1, Ziping Wang1, Le Wang2,3
1Department of Pharmacy, College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, China.
Abstract:
Human induced pluripotent stem cells (hiPSCs), similar to embryonic stem cells, are a class of pluripotent stem cells with the potential to differentiate into various kinds of cells. Because the application of hiPSCs obtained by reprogramming patients' somatic cells in the treatment of brain diseases bypasses the ethical constraints on the use of embryonic stem cells and mitigates immune rejection, hiPSCs have profound clinical application prospects. In this review, we first summarized the differentiation methods of hiPSCs into different kinds of neurons, and secondly discussed the application of hiPSCs in several brain disease models, so as to provide a reference for the future application of hiPSCs in the studies and treatment of brain diseases.
Related Concept Videos
EPS and iPS Cells in Disease Research
Induced Pluripotent Stem Cells
iPS Cell Differentiation
Stem Cell Culture

