Related Experiment Video
Updated: May 28, 2025
Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
Published on: July 14, 2021
Left ventricular remodeling in atrial fibrillation is associated with elevated NAP-2 and 3-nitrotyrosine
Patrycja Mołek-Dziadosz1, Joanna Natorska2,3, Paweł T Matusik4,5
1Department of Coronary Artery Disease and Heart Failure, Jagiellonian University Medical College, Krakow, Poland.
Background:
Atrial fibrillation (AF) coexists with left ventricular (LV) dysfunction and remodeling. Neutrophil infiltration of cardiac muscle tissue and oxidative stress are associated with cardiac remodeling.
Materials And Methods:
In 221 AF patients aged 70 (62-76) years, LV remodeling was assessed using echocardiography. Plasma concentrations of neutrophil-activating peptide 2 (NAP-2) and 3-nitrotyrosine were measured.
Results:
AF patients with concentric and eccentric hypertrophy showed higher NAP-2 levels than those with normal LV geometry (+41% and + 29%, p = 0.001 and p = 0.025, respectively). Moreover, concentric hypertrophy was associated with 85% higher 3-nitrotyrosine level (p = 0.01) compared to normal LV geometry.
Conclusions:
Elevated NAP-2, associated with oxidative damage, may contribute to the development of LV hypertrophy.
More Related Videos
12:45Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
Published on: December 11, 2017
10:39Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding
Published on: August 30, 2024
