Visible light-induced photoisomerization of indole-oxindole constructs: molecular disassembly and ROS-mediated
Kartikay Tyagi1, Tejal Dixit1, V Venkatesh1
1Laboratory of Chemical Biology and Medicinal Chemistry, Department of Chemistry, Indian Institute of Technology Roorkee, Uttarakhand-247667, India. venkatesh.v@cy.iitr.ac.in.
Abstract:
Indole-oxindole constructs (IOCs) have been formulated, showcasing their potential of light mediated photoisomerization. The unusual intramolecular hydrogen bonding interaction present in IOCs facilitates the exclusive synthesis of Z-isomers. IOC-4-Z stands out with its excellent photophysical characteristics due to its aggregation-induced emission (AIE) features. Upon blue light irradiation, it undergoes molecular disassembly and produces ROS to exhibit a chemo-phototherapeutic effect.
Related Concept Videos
Cycloaddition Reactions: MO Requirements for Photochemical Activation
Photochemical Electrocyclic Reactions: Stereochemistry
Selection Rules: Photochemical Activation
Photoreceptors and Visual Pathways


