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Bidirectional causal associations between frailty measures and sleep disturbances: a two-sample Mendelian
Lu Che1, Han Zang1, Yaodan Bi1
1Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, People's Republic of China.
Nature and Science of Sleep
|February 12, 2025
Summary
This study used Mendelian randomization to investigate causality between frailty and sleep disturbances. Findings suggest a bidirectional relationship, meaning frailty impacts sleep and sleep impacts frailty.
Area of Science:
- Gerontology
- Sleep Medicine
- Genetics
Background:
- Observational studies link sleep disturbances and frailty, but causality is unclear.
- Frailty is a growing concern in aging populations.
- Sleep disturbances are common in older adults.
Purpose of the Study:
- To investigate the bidirectional causal relationships between frailty measures and sleep disturbances.
- To employ a two-sample Mendelian randomization (MR) analysis for robust causal inference.
Main Methods:
- Two-sample Mendelian randomization (MR) analysis using large-scale genome-wide association studies (GWAS) data.
- Examined frailty index (FI) and Fried Frailty Score (FFS) against insomnia, sleep duration, and sleep apnea.
- Utilized inverse variance-weighted (IVW) method with comprehensive sensitivity analyses.
Main Results:
- Genetically predicted frailty measures (FI, FFS) were associated with increased risk of insomnia, shorter sleep duration, and sleep apnea.
- Conversely, genetic liability to insomnia, short sleep duration, and long sleep duration were linked to increased frailty (FI, FFS).
Conclusions:
- Provided strong genetic evidence for bidirectional causality between frailty and sleep disturbances.
- Findings support integrated approaches for managing both conditions to improve health outcomes.
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