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Capillary leak syndrome due to snakebite in the Amazon: case report
Edgar A Ramírez-García1,2, Arley Perez-Mori1,3, Mónica Mori-Coral1
1Universidad Nacional de la Amazonia Peruana, Loreto, Perú.
Revista Peruana De Medicina Experimental Y Salud Publica
|February 12, 2025
Summary
Capillary leak syndrome, a complication of snakebite envenoming, caused severe facial edema in a Peruvian boy. Prompt antivenin treatment led to a full recovery, highlighting effective management of this rare condition.
Area of Science:
- Toxicology
- Clinical Medicine
- Herpetology
Background:
- Capillary leak syndrome (CLS) is a rare but serious condition characterized by plasma leakage into the interstitial space.
- Snakebite envenoming, particularly from Bothrops species, is a known cause of CLS.
- Early recognition and treatment are crucial for managing severe envenomation.
Observation:
- A 12-year-old boy in the Peruvian Amazon presented with severe facial edema and swelling following a snakebite on his leg.
- The snake was identified as belonging to the Bothrops genus.
- The patient was diagnosed with severe ophidism complicated by facial edema.
Findings:
- The patient received eight vials of antivenin, antibiotics, and analgesics.
- Hospitalization lasted for eight days.
- The patient showed a favorable clinical evolution and complete recovery.
Implications:
- This case underscores the importance of prompt medical attention for snakebite victims, especially in remote areas.
- Effective antivenom therapy is critical in managing severe envenomation and its complications like CLS.
- Understanding the clinical presentation and management of CLS in snakebite cases is vital for healthcare providers in endemic regions.

