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A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
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Sigma-1 Receptor Specific Biological Functions, Protective Role, and Therapeutic Potential in Cardiovascular Diseases

Ahmed Almaamari1, Marwa Sultan1, Tao Zhang1

  • 1Department of Pharmacology, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, The Key Laboratory of New Drug Pharmacology and Toxicology, Hebei Medical University, Shijiazhuang, 050017, Hebei, China.

Cardiovascular Toxicology
|February 12, 2025
PubMed

Insights

The sigma-1 receptor (S1R) shows promise in treating cardiovascular disease (CVD). Activating S1R may offer protective benefits, guiding future clinical trials for heart conditions.

Area of Science:

  • Cardiology
  • Pharmacology
  • Molecular Biology

Background:

  • Cardiovascular disease (CVD) is a major global health burden, necessitating novel therapeutic strategies.
  • The sigma-1 receptor (S1R) is implicated in cardiac pathophysiology, including hypertrophy, heart failure, and remodeling.

Purpose of the Study:

  • To review the mechanisms underlying S1R's role in cardiovascular disease.
  • To explore how S1R pathway modulation confers cardiovascular protection.
  • To inform the development of new CVD therapeutic agents targeting S1R.

Main Methods:

  • Literature review of preclinical and clinical studies on S1R and CVD.
  • Analysis of molecular pathways influenced by S1R activation in the cardiovascular system.

Main Results:

  • Preclinical evidence indicates S1R activation exerts beneficial cardiovascular effects.
  • S1R modulation influences key pathways involved in cardiac protection.

Conclusions:

  • S1R represents a promising therapeutic target for cardiovascular diseases.
  • Understanding S1R mechanisms can accelerate the development of effective CVD treatments.

Keywords:
Cardiovascular diseasesChaperoneEndoplasmic reticulumMitochondria association membraneSigma-1 receptor

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