From traditional to modern: Nanotechnology-driven innovation in mycotoxin sensing for Chinese herbal medicines

Mycotoxin contamination in Chinese herbal medicines (CHMs) is a pressing concern that jeopardizes their quality and safety, despite their widespread therapeutic use. Conventional detection methods are often limited by complexity, cost, and sensitivity, particularly in resource-limited settings. This gap in effective and efficient mycotoxin detection necessitates a comprehensive review that explores innovative solutions to enhance the safety and efficacy of CHMs. Advancements in nanomaterials and related advanced sensing techniques have emerged as a beacon of hope. Therefore, this review aims to fill the knowledge gap by providing a comprehensive overview of the latest developments in mycotoxin detection in CHMs, spotlighting the transformative role of nanomaterials and advanced sensing techniques. This review stands out for its in-depth exploration of functional nanomaterials across dimensions and their innovative applications in mycotoxin detection. Its innovation stems from a holistic approach that not only surveys current technologies but also charts a forward-looking path, emphasizing novel nanomaterial development, refined pretreatment, and advanced biosensing for on-site detection. It delves into the integration of nanomaterials with advanced sensing technologies, discussing the advantages and limitations of these approaches. A significant innovation of this review lies in the nuanced integration of nanomaterials with machine learning and artificial intelligence, revealing untapped potential for accuracy enhancement. Through this synthesis of knowledge, we hope to inspire further research and development in this critical area, ensuring the continued safe use of CHMs in traditional medicine practices.