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Updated: May 28, 2025

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Stereoselective Synthesis of Benzoylated Gulmirecin A and Disciformycin B
Klaus-Peter Rühmann1, Kaijie Ji1, Dirk Trauner1
1Department of Chemistry, New York University, New York, New York 10003, United States.
Abstract:
Disciformycins and gulmirecins are potent inhibitors of the bacterial RNA polymerase. They show promising activities against multidrug-resistant pathogens often found in clinical settings, such as methicillin- and vancomycin-resistant Staphylococcus aureus (MRSA and VRSA). Our modular, high-yielding, and scalable synthetic approach started with the desymmetrization of divinyl carbinol and provided benzoylated precursors for both natural product classes. The 12-membered macrocycle was assembled by a stereoselective Nozaki-Hiyama-Takai-Kishi macrocyclization.
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