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Post-streptococcal glomerulonephritis following pyoderma.

H C Dillon

    Reviews of Infectious Diseases
    |November 1, 1979
    PubMed
    Summary
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    Acute glomerulonephritis (AGN) epidemiology shows streptococcal skin infections are common in young children and caused by specific M-serotypes, distinct from throat infections. These skin infections are important in AGN but do not cause acute rheumatic fever.

    Area of Science:

    • Infectious Diseases
    • Nephrology
    • Epidemiology

    Background:

    • Acute glomerulonephritis (AGN) is a significant post-infectious kidney disease.
    • Streptococcal infections, particularly following pyoderma (skin infections), are a known cause of AGN.
    • Understanding the epidemiology and specific serotypes involved is crucial for prevention and management.

    Purpose of the Study:

    • To review studies on the epidemiology of acute glomerulonephritis following pyoderma over the past 15 years.
    • To elucidate the natural history of streptococcal skin infections and their role in AGN.
    • To identify differences between streptococcal skin and throat infections in relation to AGN.

    Main Methods:

    • Systematic review of epidemiological studies on acute glomerulonephritis following pyoderma.

    Related Experiment Videos

  • Analysis of investigations from Alabama, Red Lake (Minnesota), and Trinidad.
  • Comparison of clinical and microbiological data from skin versus pharyngeal streptococcal infections.

    • Main Results:

    • Streptococcal skin infections are a notable cause of AGN, particularly in young preschool children.
    • Specific M-serotypes (2, 49, 55, 57, 60) are now recognized as important in AGN following pyoderma, differing from those (M-types 1, 12) associated with pharyngitis-related AGN.
    • Unlike pharyngeal infections, streptococcal skin infections leading to AGN do not result in acute rheumatic fever.

    Conclusions:

    • Streptococcal pyoderma represents a distinct epidemiological entity compared to streptococcal pharyngitis in the context of AGN.
    • Identification of specific M-serotypes involved in pyoderma-associated AGN is critical for targeted interventions.
    • While significant in AGN, streptococcal skin infections do not appear to be a precursor to acute rheumatic fever.