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Six new metabolites from Ganoderma lucidum-derived endophytic Trichoderma sp. GLQ02 and their anti-inflammatory
Xin-Huan Qiu1, Xia Cheng2, Qi Luo3
1Department of Pharmacy, Clinical Pharmacy Center, Nanfang hospital, Southern Medical University, Guangzhou 510515, China.
Abstract:
Six undescribed trichophthalides A-F (1-6) and a known phthalide derivative (7) were isolated from Ganoderma lucidum-derived endophytic Trichoderma sp. GLQ02. Among them, meroterpenoids 1, 3, 4, 6, and 7 possessed an independent isoprenyl unit with varying degrees of oxidation. The structures and absolute configurations of these substances were elucidated on the basis of spectroscopic data, ECD and DP4+ calculations. Finally, compounds 1, 5, and 7 exhibited relatively weak abilities to inhibit the production of NO in LPS-stimulated RAW 264.7cells at a concentration of 60 μM.
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