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Related Experiment Videos

Antifungal sensitivity testing for equine keratomycosis.

C T Coad, N M Robinson, K R Wilhelmus

    American Journal of Veterinary Research
    |March 1, 1985
    PubMed
    Summary

    Equine fungal keratitis cases increased in the 1980s, with Aspergillus being the most common genus. Imidazole antibiotics like miconazole were most effective against filamentous fungi in vitro.

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    Prevalence and spectrum of bacterial co-infection during fungal keratitis.

    The British journal of ophthalmology·2006

    Area of Science:

    • Veterinary Ophthalmology
    • Mycology
    • Infectious Diseases

    Background:

    • Fungal keratitis is a significant cause of corneal disease in horses.
    • A decade-long study (1973-1983) analyzed fungal isolates from equine corneas.
    • A trend of increasing fungal infection frequency was observed during the 1980s.

    Purpose of the Study:

    • To identify fungal genera and species causing equine corneal infections.
    • To evaluate the in vitro efficacy of imidazole antibiotics against these fungal isolates.
    • To provide guidance for optimal antifungal therapy in horses.

    Main Methods:

    • Collection and identification of 31 fungal specimens from equine corneas over a 10-year period.
    • Determination of tube-dilution minimal inhibitory concentrations (MICs) and minimal fungicidal concentrations (MFCs) for 16 isolates.
    • Testing of imidazole antibiotics, including miconazole and ketoconazole.

    Main Results:

    • Aspergillus was the most prevalent genus (35%), with 13 genera and 20 species identified overall.
    • Imidazole antibiotics demonstrated the lowest geometric mean titers against filamentous fungi.
    • Significant variation in fungal sensitivity to antifungals was observed across different species.

    Conclusions:

    • Fungal keratitis in horses, particularly caused by Aspergillus, warrants attention.
    • In vitro antifungal sensitivity testing is crucial for selecting effective treatments.
    • Imidazole antifungals show promise for treating equine fungal keratitis.

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