Related Experiment Video

Updated: May 28, 2025

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research
06:51

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research

Published on: October 20, 2023

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Aortic Stenosis Prevention: Is a New Cardiovascular Disease Paradigm Coming of Age?

Antonios Halapas1, Dennis V Cokkinos2

  • 1Department of Interventional Cardiologist and THV Program, Athens Medical Center, 11526 Athens, Greece.

Journal of Clinical Medicine
|February 13, 2025
PubMed

Insights

Calcific aortic stenosis (CAS) is a common cardiovascular issue in older adults. This review details CAS pathophysiology and explores preventive strategies beyond surgery.

Area of Science:

  • Cardiovascular Medicine
  • Geriatrics
  • Pathophysiology

Background:

  • Calcific aortic stenosis (CAS) affects over 30% of individuals over 60.
  • It is the third most common cardiovascular disorder in the elderly.
  • CAS involves complex fibro-calcific remodeling of aortic valve leaflets.

Purpose of the Study:

  • To present a comprehensive review of CAS pathophysiology.
  • To explore potential preventive strategies for CAS.
  • To discuss alternatives to surgical and interventional treatments for CAS.

Main Methods:

  • Literature review of current research on CAS.
  • Analysis of pathophysiological mechanisms.
  • Identification and evaluation of preventive strategies.

Main Results:

  • CAS is an active, multifactorial process.
  • Key factors include hemodynamics, genetics, inflammation, and osteoblastic transformation.
  • Several preventive strategies are under investigation.

Conclusions:

  • Understanding CAS mechanisms is crucial for developing new treatments.
  • Preventive approaches may offer alternatives to current interventions.
  • Further research is needed to validate preventive strategies.

Keywords:
aortic stenosisdiagnosismanagementpathophysiologyprevention

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