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Related Experiment Video

Updated: May 28, 2025

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Published on: December 17, 2010

Immunotherapy-Related Hypophysitis: A Narrative Review.

Vincenza Di Stasi¹, Domenico La Sala², Renato Cozzi³

¹Center of Nutrition for the Research and the Care of Obesity and Metabolic Diseases, National Institute of Gastroentherology IRCCS Saverio De Bellis, 70013 Castellana Grotte, Italy.

|February 13, 2025

Summary

Immune checkpoint inhibitors (ICIs) can cause hypophysitis, a detrimental endocrine side effect. Early diagnosis and hormone replacement are crucial for managing this condition and preserving patient quality of life.

Keywords:

hypophysitis immune checkpoint inhibitors immunotherapy

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Last Updated: May 28, 2025

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Published on: December 17, 2010

Induction of Experimental Autoimmune Hypophysitis in SJL Mice

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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

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Published on: March 17, 2023

Area of Science:

Oncology
Endocrinology
Immunology

Background:

Immune checkpoint inhibitors (ICIs) have transformed cancer treatment.
Immune-related adverse events (irAEs) are a significant concern with ICIs.
Hypophysitis is a detrimental endocrine irAE affecting the pituitary gland.

Purpose of the Study:

To synthesize current knowledge on ICI-induced hypophysitis (IH).
To review the pathogenesis, clinical features, diagnosis, and management of IH.
To enhance awareness and guide clinical practice for IH.

Main Methods:

Narrative review of recent literature and clinical trials.
In-depth analysis of diagnostic challenges and overlapping symptoms.
Synthesis of management strategies including hormone replacement and monitoring.

Main Results:

IH diagnosis is challenging due to symptom overlap with malignancy.
Diagnostic evaluation involves clinical assessment, hormonal profiling, and MRI.
Management requires a multidisciplinary approach with hormone replacement and monitoring.

Conclusions:

Early recognition and timely intervention are vital for managing IH.
Personalized, multidisciplinary care is essential for optimal patient outcomes.
Effective management can mitigate long-term effects on quality of life.