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Histamine and 5-hydroxytryptamine in human scar tissue.
Annals of Plastic Surgery
|March 1, 1985
Summary
Histamine and serotonin levels are elevated in unstable scars, contributing to patient itchiness and pain. These findings highlight the role of these substances in scar tissue conditions.
Area of Science:
- Biochemistry
- Dermatology
- Wound Healing
Background:
- Unstable scars can cause significant patient discomfort, including itchiness and pain.
- Histamine and serotonin are suspected contributors to scar-related symptoms.
Purpose of the Study:
- To quantify histamine and serotonin levels in scar tissue under various conditions.
- To investigate the relationship between these substances and scar stability.
Main Methods:
- Histamine levels were assessed via histidine decarboxylase activity (HDCA) by measuring carbon dioxide production.
- 5-hydroxytryptamine (5-HT) levels were determined using the Ninhydrin method.
Main Results:
- Elevated HDCA was frequently observed in skin flaps and scar tissue around pressure sores.
- 5-HT activity was significantly higher in unstable scars compared to stable scars.
Conclusions:
- Histamine and serotonin are implicated in the pathophysiology of unstable scars.
- Quantifying these substances may aid in understanding and managing scar-related symptoms.