Recent Advances in Food Safety Detection: Split Aptamer-Based Biosensors Development and Potential Applications

Area of Science:

• Biotechnology
• Analytical Chemistry
• Food Science

Background:

• Traditional food safety detection methods suffer from slow speeds, high costs, and low accuracy.
• There is a critical need for advanced technologies to ensure food safety.
• Aptamers and aptasensors present viable alternatives to conventional detection techniques.

Purpose of the Study:

• To review the advancements in aptamer and aptasensor technology for food safety.
• To highlight the application of aptamers in detecting small molecules.
• To explore split aptamers as an innovative solution for small-molecule detection challenges.

Main Methods:

• Review of current literature on aptamers and aptasensors in food safety.
• Analysis of strategies for aptamer modification and optimization.
• Examination of split aptamer development and integration into aptasensor platforms.

Main Results:

• Aptamers offer high specificity and affinity for target molecules.
• Aptasensors provide rapid, cost-effective, and sensitive detection of food contaminants.
• Split aptamers enhance detection of small molecules by overcoming steric hindrance and non-specific binding.

Conclusions:

• Split aptamers represent a significant advancement in food safety detection technology.
• These engineered aptamers effectively address the limitations of traditional methods for small molecule analysis.
• Further development and integration of split aptasensors promise to enhance global food safety surveillance.