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Published on: November 21, 2013
Cholesterol metabolism and its implications in psychotic disorders: a comparative study of individuals at ultra high
Mislene Bispo Teixeira Moreno1,2, Monique Patricio Singulani1,2,3, Martinus Theodorus van de Bilt1,2
1Laboratory of Neuroscience, Department and Institute of Psychiatry, Instituto de Psiquiatria, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), LIM-27)Rua Dr. Ovídio Pires de Campos, 785, São Paulo, SP-05403-010, Brazil.
Abstract:
Psychotic disorders, particularly schizophrenia, are characterized by significant cognitive and social impairments, with early identification being crucial for effective intervention. Cholesterol plays a vital role in brain function and is primarily synthesized within the central nervous system. We analyzed plasma levels of total cholesterol and specific oxysterols, including 24-hydroxycholesterol, 27-hydroxycholesterol, and others, in a cohort of 61 ultra-high risk individuals and 44 healthy controls. Our findings indicate no difference in total cholesterol levels between groups; however, ultra-high risk individuals exhibited significantly increased levels of all measured oxysterols, suggesting dysregulation of cholesterol metabolism. Furthermore, a weak correlation was found between 27-hydroxycholesterol levels and positive psychotic symptoms. These results highlight the potential role of altered cholesterol metabolism in the early stages of psychotic disorders, proposing that specific oxysterols may serve as biomarkers for early detection and intervention strategies. This study contributes to the understanding of the biochemical underpinnings of psychosis and emphasizes the need for further investigation related to lipid metabolism and psychotic disorders.
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