Related Experiment Video
Updated: May 28, 2025

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
Published on: August 23, 2024
Morroniside restrains renal glucose reabsorption to regulate glucose metabolism via the PPARδ/SGLT2 signaling pathway
Bing Yu1, Yukai Cui1, Liyu Lin1
1Department of Nephrology, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, 361015, Fujian Province, China; Xiamen Clinical Quality Control Center of Nephrology, Xiamen, 361015, Fujian Province, China.
Abstract:
Morroniside (Mor) has been documented to has anti-diabetic activity. Nevertheless, the impact of Mor on the glucose metabolism and its underlying mechanism have never been elucidated. Here, we demonstrated that Mor improved the body weight, hyperglycemia, and insulin resistance in rat model of T2DM. Furthermore, Mor restrained renal glucose reabsorption of T2DM rats, accompanied by PPARδ upregulation and SGLT2 downregulation in renal tissues. The protein level of PPARδ was decreased, but SGLT2 was increased in HK-2 cells underwent high glucose stimulation. Mor enhanced PPARδ expression and inhibited SGLT2 expression in HK-2 cells under high glucose condition. PPARδ silencing rescued, but SGLT2 silencing reinforced the inhibitory effect of Mor on glucose uptake of HK-2 cells. In conclusions, Mor restrains renal glucose reabsorption to regulate glucose metabolism by regulating the PPARδ/SGLT2 signaling pathway, manifesting that Mor may be a promising therapeutic medicine for T2DM.
More Related Videos
07:30Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion
Published on: May 10, 2018
10:37Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
Related Concept Videos
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are...
Dipeptidyl Peptidase 4 Inhibitors
Glucagon-like Receptor Agonists
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
Oral Hypoglycemic Agents: Biguanides and Glitazones
Oral Hypoglycemic Agents: Glinides
Glucose Transporters
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes: