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Delayed onset of non-cardiogenic pulmonary oedema following amlodipine overdose
Luca Danilo Zambetti1, Andrew Graham Parrish2
1Internal Medicine, Cecilia Makiwane Hospital, Mdantsane, Eastern Cape, South Africa lucadzam@gmail.com.
Abstract:
Amlodipine, a widely used antihypertensive medication, can cause serious complications in overdose, including hypotension, bradycardia, non-cardiogenic pulmonary oedema (NCPO) and death. This report describes a young adult woman who ingested 100 mg of amlodipine in a polypharmacy suicide attempt. Although she initially stabilised, she unexpectedly developed delayed NCPO 3 days post ingestion, requiring intubation and intensive care unit readmission. She recovered fully with supportive care and was discharged in good health. This case highlights the importance of prolonged monitoring and vigilance in managing long-acting calcium channel blocker overdoses, even when the initial clinical response appears satisfactory.
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