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Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies

Humanized NOD/SCID/IL2rγ^null (hu-NSG) Mouse Model for HIV Replication and Latency Studies

Published on: January 7, 2019

Unexpected HBsAg decrease after nucleoside analogues retreatment among HBeAg positive postpartum women: a pilot

Qiao Tang¹, Chunrui Wang¹, Hu Li¹

¹Department of Infectious Diseases, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Virology Journal

|February 13, 2025

Summary

This summary is machine-generated.

Discontinuing nucleoside analogue (NA) treatment for chronic hepatitis B (CHB) postpartum is safe. Retreatment with NAs after stopping treatment can lead to significant decreases in hepatitis B surface antigen (HBsAg), aiding functional cure.

Keywords:

ALT abnormal Liver fibrosis Mother-to-child transmission Treatment discontinuation Virologic response

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Area of Science:

Hepatology
Virology
Maternal-Fetal Medicine

Background:

Mother-to-child transmission (MTCT) of Hepatitis B Virus (HBV) is a significant concern.
Previous research on nucleoside analogues (NAs) for preventing MTCT in chronic hepatitis B (CHB) is limited.
Data on virologic changes after discontinuing NA treatment postpartum and retreatment efficacy are scarce.

Purpose of the Study:

To investigate the virologic changes in CHB patients after discontinuing NA treatment postpartum.
To evaluate the efficacy of NA retreatment in CHB patients.
To assess the safety of discontinuing NA treatment postpartum for HBeAg positive pregnant patients.

Main Methods:

A retrospective-prospective real-world pilot cohort study was conducted.
Included pregnant women with CHB who received NAs pre-pregnancy, discontinued treatment postpartum, or underwent retreatment.
Collected biochemical and virological data (HBsAg, HBeAg, HBV DNA) during follow-up.

Main Results:

Postpartum discontinuation of NA treatment showed low incidences of HBeAg clearance and HBsAg reduction.
Retreatment patients exhibited significantly greater decreases in HBsAg, HBeAg, and HBV DNA compared to pre-pregnancy treatment.
Higher cumulative incidences of HBsAg reduction were achieved in retreatment patients.
Discontinuing treatment postpartum was found to be safe for HBeAg positive pregnant patients.

Conclusions:

HBeAg positive patients discontinuing postpartum NA treatment can benefit from subsequent NA retreatment.
Retreatment can lead to significant HBsAg decrease, potentially contributing to functional cure.
Postpartum NA discontinuation is a safe strategy for CHB patients.