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Updated: May 28, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Electrochemical Aminooxygenation of Enamides
Yong Yuan1, Feng Zhang1, Xincong Liu1
1College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, China.
Abstract:
Herein, we present an unprecedented electrochemical approach for aminooxygenation of enamides with azoles under transition-metal- and oxidizing-reagent-free conditions. This method affords 4-azolated oxazolines directly from readily available starting materials in up to 95% yield. Central to our success is the utilization of electrical energy as the primary driving force and NaBr as a mediator. Importantly, the resulting 4-azolated oxazolines exhibit potential utility as ligands (pyrazole-oxazoline ligands) in transition-metal-catalyzed reactions.
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