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Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
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Cancer-specific dual-factor cascade recognition fluorescent probe for imaging and tumor diagnosis
Ziqian Wang1, Yitong Li2, Hong Zhang1
1Central Hospital of Dalian University of Technology, School of Pharmacy, Faculty of Medicine, Dalian University of Technology, Dalian, Liaoning, 116024, China. zczhang@dlut.edu.cn.
Chemical Communications (Cambridge, England)
|February 14, 2025
Abstract:
Herein, we developed a dual-factor recognition activatable probe, S1-F, which accurately lights up Bcl-2 and GSH dual-overexpressed cancer tissue with a superior tumor-to-normal tissue (T/N) ratio, highlighting the potential for this probe to be used in the visual diagnosis and imaging-guided surgery of cancer.
