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Continuous-wave Thulium Laser for Heating Cultured Cells to Investigate Cellular Thermal Effects

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CO2 Fractional Laser Induced Skin Micro-Tunnel Thermal Damage Patterns: A Simulation Study.

Ali Shorakaie¹, Elaheh Nahvifard¹, Afshan Shirkavand²

¹Physics Department, Science Faculty, Imam Khomeini International University, Qazvin, Iran.

Journal of Lasers in Medical Sciences

|February 14, 2025

Summary

Optimizing CO2 fractional laser settings, specifically 10W power and longer pulse durations, creates effective micro-tunnels for drug delivery while minimizing thermal damage to skin tissue.

Keywords:

COMSOL Fractional laser Simulation Thermal damage Thermal distribution

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Area of Science:

Biomedical Engineering
Dermatology
Laser Physics

Background:

Fractional CO2 lasers create micro-tunnels for rejuvenation and drug delivery.
Understanding heat distribution and thermal damage is crucial for optimizing laser treatments.
Minimizing collateral thermal damage is essential for safe and effective laser procedures.

Purpose of the Study:

To simulate heat distribution and thermal damage models for CO2 fractional lasers.
To optimize laser parameters (size, pulse duration, power) for improved drug delivery applications.
To evaluate the impact of different laser settings on tissue preservation.

Main Methods:

Utilized COMSOL Multiphysics software for thermal modeling.
Modeled skin as three homogeneous layers: epidermis, dermis, and hypodermis.
Defined parameters including 0.07 mm spot size, 10-15 W power, and 0.5-15 ms pulse durations.

Main Results:

10 W power with varied pulse durations yielded optimal micro-tunnels with minimal injury.
Higher power (>15 W) and short pulses (e.g., 5 pulses) led to significant tissue damage.
Increased pulse duration at 10 W power reduced surrounding tissue damage.

Conclusions:

CO2 fractional lasers induce micro-tunnels via absorbed light and heat generation.
Greater spacing between micro-tunnels correlates with better tissue preservation.
COMSOL software shows promise for preclinical laser treatment optimization.