Complex NADASE Infusions Improve Clinical Outcome in Substance Use Disorder: Descriptive Annotation in Fifty Cases

The present study relates to a method to treat and detoxify patients with substance use disorder (SUD) utilizing a series of nicotinamide adenine dinucleotide (NAD+) and enkephalinase infusions (NADASE) in subjects attending chemical dependency programs.

The primary objective of the current investigation is to provide some additional clinical evidence to show that NAD+ other amino acids including d-phenylalanine, glycine and ananylglutamine dipeptide and Myer's cocktail (B complex) infusions significantly attenuates substance craving behavior and concomitant psychiatric burden sequalae in poly-drug abusers attending both in-patient and out-patient level of care in a number of chemical dependency programs in orange country.

At symmetry approximately 1,000 now performed approximately 1,000 infusions on 900 patients without any serious side effects pointing to the safety of this procedure. The study cohort (n = 50) as a subgroup consisted of highly addicted poly-drug mixed gender and varied ethnic individuals previously resistant to standard treatment with a range of failed treatment attempts from one to ten. Each patient included in this study received a minimum of 7 infusions for an average duration of four weeks. The data includes craving scores, anxiety, depression, and sleep. We utilized likert scales (1 - 10) self-reported responses, accomplished via a counselor to patient structured interview.

In summary considering all fifty subjects using wilcoxon signed rank tests and sign tests, we found the following significance comparing the baseline scores to post outcome scores after NAD infusions; craving scores (P = 1.063E-9); anxiety (P = 5.487E-7); and depression (P = 1.763E-4). There was an improvement trend in the number of sleep hours post infusions, it was non-significant (Pre 6.28, and post 7.34). Importantly, urine analysis of a standard panel of illicit drugs of abuse during the course of NAD infusions resulted in a subset of 40 patients tested at midway during infusions 100% of these patients tested negative.

These annotated notes serve an important function showing patient to patient similarities and differences and contribute to the emerging literature concerning NAD efficacy in SUD.