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Using Tomoauto: A Protocol for High-throughput Automated Cryo-electron Tomography
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Evolution of tomosynthesis.

Mitchell M Goodsitt1, Andrew D A Maidment2

  • 1University of Michigan, Department of Radiology, Ann Arbor, Michigan, United States.

Journal of Medical Imaging (Bellingham, Wash.)
|February 14, 2025
PubMed
Summary
This summary is machine-generated.

Tomosynthesis, a medical imaging technique, overcomes X-ray limitations by reducing structure overlap. This review traces its historical development and future potential in various applications.

Keywords:
imagingtomosynthesisx-ray

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Area of Science:

  • Medical Imaging
  • Radiology
  • Diagnostic Imaging

Background:

  • Conventional single-projection X-ray imaging suffers from structure overlap, limiting diagnostic clarity.
  • Tomosynthesis, a limited-angle multi-projection method, was developed to overcome this inherent limitation.
  • Understanding the historical trajectory of tomosynthesis is crucial for appreciating its current capabilities and future potential.

Purpose of the Study:

  • To trace the historical evolution of tomosynthesis from its inception to future predictions.
  • To review key technical advances and clinical applications of tomosynthesis throughout its history.
  • To provide a foundational overview for a special issue on digital tomosynthesis.

Main Methods:

  • Historical review of tomosynthesis, citing relevant scientific literature.
  • Discussion of technical innovations, including early systems, digital detectors, and reconstruction methods.
  • Exploration of diverse clinical applications, from chest imaging to dental and radiotherapy.

Main Results:

  • Tomosynthesis originated in the mid-1930s with contributions from Ziedses des Plantes and Kaufman.
  • Significant developments include respiratory-gated systems, film-based and digital detector systems, and coded aperture techniques.
  • Current and emerging applications span breast, body, orthopedic, dental, and radiotherapy imaging, with advancements in contrast-enhanced and multimodal imaging.

Conclusions:

  • Tomosynthesis possesses a rich and ongoing history of innovation in medical imaging.
  • The technology has evolved significantly, offering improved diagnostic capabilities over conventional X-rays.
  • Future advancements promise further enhancements in imaging quality and clinical utility, particularly in breast imaging.