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Newborn screening for inborn errors of immunity in Brazil

Carolina Sanchez Aranda1, Mariana Gouveia-Pereira Pimentel2, Rafaela Rola Guimaraes1

  • 1Division of Allergy, Clinical Immunology, and Rheumatology, Department of Pediatrics, Federal University of São Paulo Medical (UNIFESP) Escola Paulista de Medicina, São Paulo, Brazil.

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
|February 14, 2025
PubMed
Summary

No abstract available in PubMed .

Keywords:
SCIDchildrenepidemiologyimmunodeficiencynewborn screening

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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
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