Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ELF-3 and TSC-1 as potential markers of recurrence in low-risk non-muscle-invasive bladder cancer.

BMC cancer·2026
Same author

LuminaConsent: AI-driven standardization and quality enhancement of urological informed consent documentation.

Northern clinics of Istanbul·2026
Same author

Long-term outcomes of percutaneous nephrolithotomy and disease management in pediatric cystine stone patients: A 25-year single-institution experience.

Journal of pediatric urology·2026
Same author

An Overview of Robotic Surgery in Pediatric Urology: Techniques, Outcomes, and Future Prospects.

Turkish archives of pediatrics·2026
Same author

Management and Outcomes of Iatrogenic Ureteral Injuries after Ureterorenoscopic Stone Surgery: A Multicenter Retrospective Analysis.

Journal of endourology·2026
Same author

Intraoperative reaction time of the surgeon during retrograde intrarenal surgery.

BMC urology·2026
Same journal

Incidence and Risk Factors for Incisional Hernia Development in Liver Transplant Recipients: A Systematic Review and Proportional Meta-Analysis.

Journal of laparoendoscopic & advanced surgical techniques. Part A·2026
Same journal

Magnetic Side-to-Side Duodeno-Ileostomy with the MagDI System: A Technical Description of the Initial Experience in Argentina.

Journal of laparoendoscopic & advanced surgical techniques. Part A·2026
Same journal

Laparoscopic Management of Pediatric Noncommunicating Hydrocele: A Comparative Study of Hydrocelectomy Versus Aspiration.

Journal of laparoendoscopic & advanced surgical techniques. Part A·2026
Same journal

Endoloop Fenestration Versus Barbed Suture Reconstitution in Laparoscopic Subtotal Cholecystectomy: A Comparative Analysis of Complications and Outcomes.

Journal of laparoendoscopic & advanced surgical techniques. Part A·2026
Same journal

Intraperitoneal Onlay Mesh Plus Repair Versus Transabdominal Preperitoneal Mesh Plus Repair in Patients with Primary Midline Ventral Hernia: A Prospective Randomized Controlled Study.

Journal of laparoendoscopic & advanced surgical techniques. Part A·2026
Same journal

Holmium Laser Enucleation of the Prostate Versus Robot-Assisted Simple Prostatectomy for Benign Prostatic Obstruction: A Systematic Review and Meta-Analysis with Trial Sequential Analysis.

Journal of laparoendoscopic & advanced surgical techniques. Part A·2026
See all related articles

Related Experiment Video

Updated: Jun 22, 2026

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

Does the 5-Item Modified Frailty Index Predict Adverse Outcomes after Retrograde Intrarenal Surgery? A Case-Control

Cem Başataç1, Muhammed Fatih Şimşekoğlu2, Kerem Teke3

  • 1Faculty of Medicine, Department of Urology, Demiroglu Bilim University, Istanbul, Turkey.

Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
|February 14, 2025
PubMed
Summary
This summary is machine-generated.

Severely frail patients undergoing retrograde intrarenal surgery for upper tract stones experience similar outcomes and complication rates compared to non-frail patients. This indicates the procedure

Keywords:
endourologyfrailtyindexretrograde intrarenal surgeryurolithiasis

More Related Videos

Identifying Frailty Using Point-of-Care Ultrasonography: Image Acquisition and Assessment
04:00

Identifying Frailty Using Point-of-Care Ultrasonography: Image Acquisition and Assessment

Published on: July 26, 2024

Frailty Assessment in an Aging Mouse Model
06:58

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

Related Experiment Videos

Last Updated: Jun 22, 2026

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

Identifying Frailty Using Point-of-Care Ultrasonography: Image Acquisition and Assessment
04:00

Identifying Frailty Using Point-of-Care Ultrasonography: Image Acquisition and Assessment

Published on: July 26, 2024

Frailty Assessment in an Aging Mouse Model
06:58

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

Area of Science:

  • Urology
  • Surgical Outcomes
  • Geriatric Surgery

Background:

  • Frailty is increasingly recognized as a significant factor influencing surgical outcomes.
  • Assessing the impact of frailty on patients undergoing minimally invasive urological procedures is crucial for risk stratification.

Purpose of the Study:

  • To evaluate the association between frailty and complications or surgical outcomes in patients undergoing retrograde intrarenal surgery (RIRS) for upper tract urinary stones.
  • To determine if severely frail patients have worse outcomes after RIRS.

Main Methods:

  • Retrospective analysis of 340 patients undergoing RIRS for upper tract stones.
  • Frailty assessed using the 5-item modified frailty index (mFI-5), with patients categorized as frail (mFI-5 ≥2) or non-frail (mFI-5 <2).
  • Comparison of operative outcomes, complication rates, and stone-free rates between frail and non-frail groups after matching confounding factors.

Main Results:

  • After matching, 255 non-frail and 85 frail patients were analyzed.
  • No significant differences were observed in operation time, length of hospital stay, intraoperative complications (7.6% vs 9.4%), postoperative complications (13.8% vs 11.8%), or stone-free rates (70.9% vs 72.9%) between the groups.
  • Baseline characteristics were similar between the frail and non-frail cohorts.

Conclusions:

  • Retrograde intrarenal surgery demonstrates comparable safety and efficacy in severely frail patients with upper tract stones.
  • Frailty status, as defined by mFI-5 score ≥2, does not appear to be a significant predictor of adverse outcomes after RIRS.
  • RIRS is a feasible and efficient treatment option for upper urinary tract stones, even in severely frail individuals.