Related Experiment Video
Updated: May 28, 2025

Taking Advantage of Reduced Droplet-surface Interaction to Optimize Transport of Bioanalytes in Digital Microfluidics
Published on: November 10, 2014
Optimal Navigation in Microfluidics via the Optimization of a Discrete Loss
Petr Karnakov1, Lucas Amoudruz1, Petros Koumoutsakos1
1Harvard, Computational Science and Engineering Laboratory, John A. Paulson School of Engineering and Applied Sciences, Cambridge, Massachusetts 02138, USA.
Abstract:
Optimal path planning and control of microscopic devices navigating in fluid environments is essential for applications ranging from targeted drug delivery to environmental monitoring. These tasks are challenging due to the complexity of microdevice-flow interactions. We introduce a closed-loop control method that optimizes a discrete loss (ODIL) in terms of dynamics and path objectives. In comparison with reinforcement learning, ODIL is more robust, up to 3 orders faster, and excels in high-dimensional action and state spaces, making it a powerful tool for navigating complex flow environments.

