Related Experiment Video
Updated: Aug 1, 2026
09:25
Laser Nanosurgery of Cerebellar Axons In Vivo
Published on: July 28, 2014
Plasticity of cerebellar parallel fibers following developmental deficits in synaptic number
Brain Research
|May 6, 1985
Abstract:
As demonstrated previously, a deficit in the number of cerebellar granule cells that is induced by pre-and postnatal malnutrition, results in fewer but larger synapses on Purkinje cells. Here, we report that the axons of granule cells compensate this loss by generating additional dense projections enlarging the presynaptic grids. This presynaptic response is directly related to the availability of the postsynaptic contact area of the target neurons which reaches a relatively constant amount during development.
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