Exploring the psychodermatologic burden and associated psychiatric manifestations in rosacea: a systemic review

Rosacea is an inflammatory skin disorder possessing significant mental health implications, including anxiety and depression. Although the disease's link to psychiatric outcomes has been explored, recent data highlights the need for a deeper examination of underlying pathways and overall burden. This systematic review aims to synthesize and evaluate the current literature on the association between rosacea and anxiety and depression, with particular attention to establishing multidisciplinary treatment approaches. A comprehensive review of the PubMed, Embase and Web of Science databases was performed to select peer-reviewed English studies relevant to our topic. Our results reveal that anxiety and depression continue to affect a majority of rosacea patients, with certain demographic variables such as age and gender modulating psychiatric burden. The complex interaction between rosacea and its psychological outcomes is thought to rely on inflammatory mediators, lipid metabolism, and neurotropic factors. Certain treatment options, including carvedilol, paroxetine and Cortexin, may target these core processes and hence, help alleviate psychological sequalae. Bearing these insights in mind, dermatologists should focus on adopting interdisciplinary treatment plans. Future research should prioritize longitudinal designs, diverse populations, and standardized methodologies to deepen our understanding of the relationship between anxiety, depression, and rosacea.