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Visual Function Benefit After Treatment With Pegcetacoplan: Microperimetry Analysis From the Phase 3 Oaks Trial
Usha Chakravarthy1, Roy Schwartz2, Robyn H Guymer3
1From the Royal Victoria Hospital (U.C.), Queen's University of Belfast, Institute of Clinical Science, Belfast, United Kingdom.
American Journal of Ophthalmology
|February 15, 2025
Summary
Pegcetacoplan treatment significantly slowed vision loss in geographic atrophy (GA) secondary to age-related macular degeneration (AMD). Microperimetry showed reduced scotoma development and preserved retinal sensitivity in treated eyes compared to sham.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Pharmacology
Background:
- Geographic atrophy (GA) is an advanced form of age-related macular degeneration (AMD) leading to irreversible vision loss.
- Current treatments for GA are limited, highlighting the need for effective therapies to slow disease progression.
Purpose of the Study:
- To assess the efficacy of pegcetacoplan in preserving visual function in patients with GA using microperimetry.
- To evaluate the drug's impact on the development of absolute scotomas and changes in retinal sensitivity within the macula.
Main Methods:
- A post hoc analysis of data from the phase 3 OAKS randomized controlled trial was performed.
- Microperimetry endpoints were analyzed over 24 months in patients receiving monthly or every-other-month pegcetacoplan compared to sham treatment.
- Key outcomes included time to absolute scotoma development and changes in mean retinal sensitivity in the GA junctional zone.
Main Results:
- Pegcetacoplan treatment significantly delayed the onset of absolute scotomas in the central macula compared to sham (34-48% risk reduction).
- Eyes treated with pegcetacoplan developed fewer absolute scotomatous points and showed less decline in mean retinal sensitivity within the GA junctional zone.
- These benefits were observed in both monthly (PM) and every-other-month (PEOM) dosing regimens.
Conclusions:
- Pegcetacoplan demonstrated a significant benefit in slowing visual function loss in eyes with geographic atrophy.
- Microperimetry endpoints confirm pegcetacoplan's ability to preserve central visual function and retinal sensitivity in AMD-related GA.
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