Related Experiment Video
Updated: May 27, 2025
09:32
Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
Published on: September 26, 2019
7.1K
Atopic dermatitis
Emma Guttman-Yassky1, Yael Renert-Yuval2, Patrick M Brunner1
1Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Lancet (London, England)
|February 15, 2025
Summary
Atopic dermatitis, a common chronic skin condition, causes severe itch and impacts quality of life. Recent advances in understanding its pathophysiology have led to new, targeted treatments offering better disease control.
Area of Science:
- Dermatology
- Immunology
- Allergy
Background:
- Atopic dermatitis is a prevalent global chronic inflammatory skin disease.
- It is characterized by eczematous eruptions and intense itch, significantly reducing patient quality of life, particularly in moderate-to-severe cases.
- Atopic dermatitis is associated with other atopic conditions affecting respiratory and gastrointestinal systems.
Purpose of the Study:
- To discuss the updated pathophysiological understanding of atopic dermatitis.
- To review the evolving therapeutic landscape for managing this condition.
- To highlight novel targeted treatment approaches.
Main Methods:
- Review of recent scientific literature.
- Analysis of current treatment guidelines.
- Discussion of emerging therapeutic strategies.
Main Results:
- Traditional treatments relied on broad immunosuppressive agents, posing challenges for long-term control.
- Recent advancements have improved understanding of atopic dermatitis pathophysiology.
- Novel targeted treatments have been developed and approved, offering safer and more effective options.
Conclusions:
- Improved pathophysiological insights have revolutionized atopic dermatitis management.
- Novel targeted therapies represent a significant advancement over older, broad immunosuppressants.
- The evolving therapeutic landscape offers improved prospects for patients with atopic dermatitis.
Related Concept Videos
01:23Skin Diseases and Disorders
2.8K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
2.8K
01:21Accessory Structures of the Skin: Sebaceous Glands
1.7K
A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
1.7K
01:20Asthma: Pathogenesis and Management
339
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
339
01:26Asthma-II: Pathophysiology and Classification
2.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.6K
02:06Allergic Reactions
27.2K
Overview
27.2K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.7K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.7K