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Hidradenitis Suppurativa and Recurrent Peripheral Ulcerative Keratitis: A Case Report
Klara Ambaye1, Victor Cox1, Abhishek Naidu2
1Ophthalmology, Georgetown University School of Medicine, Washington, DC, USA.
Cureus
|February 17, 2025
Summary
This case report details a rare instance of hidradenitis suppurativa (HS) flare coinciding with peripheral ulcerative keratitis (PUK). Treatment with steroids resolved symptoms, suggesting HS may cause PUK.
Area of Science:
- Dermatology and Ophthalmology
- Investigating the intersection of chronic inflammatory skin diseases and ocular complications.
Background:
- Hidradenitis Suppurativa (HS) is a chronic inflammatory skin condition.
- HS is associated with various ocular manifestations, including inflammatory eye diseases (IEDs).
- The link between HS and IEDs is documented, but HS and peripheral ulcerative keratitis (PUK) association is less common.
Observation:
- A case report of a patient with a longstanding history of HS experiencing a simultaneous HS flare and PUK.
- The patient presented with symptoms of both HS and PUK.
Findings:
- The patient's ocular and skin symptoms resolved with a combination of topical and oral steroids.
- This suggests a potential causal link where HS may underlie the development of PUK.
Implications:
- This case adds to the evidence connecting HS with ocular complications.
- Peripheral ulcerative keratitis (PUK) should be recognized as a rare but significant potential manifestation of hidradenitis suppurativa (HS).

