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Optimized System for Cerebral Perfusion Monitoring in the Rat Stroke Model of Intraluminal Middle Cerebral Artery Occlusion
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Optimized System for Cerebral Perfusion Monitoring in the Rat Stroke Model of Intraluminal Middle Cerebral Artery Occlusion

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Is Laser Doppler Perfusion Imaging Truly a "Gold Standard" for Preclinical Peripheral Artery Disease Research?

Dong Gun Oh1,2, Laura Hansen1,2, W Robert Taylor1,2,3

  • 1Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

JACC. Basic to Translational Science
|February 17, 2025
PubMed
Abstract

No abstract available in PubMed .

Keywords:
femoral artery ligationhindlimb ischemiaischemiaperipheral artery disease

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...

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