Endoscopic closure using a dedicated device following gastric endoscopic submucosal dissection: Multicenter,
Kazuo Shiotsuki1,2, Kohei Takizawa3,2, Yohei Nose4
1Department of Gastroenterology, Kitakyushu Municipal Medical Center, Kitakyushu, Japan.
Endoscopy International Open
|February 17, 2025
Summary
A new FLEXLOOP device offers a feasible and safe method for closing mucosal defects after gastric endoscopic submucosal dissection (ESD). This innovative technique shows promise for simplifying defect closure, though further research is needed to confirm long-term benefits.
Area of Science:
- Gastroenterology
- Endoscopic Surgery
- Medical Device Development
Background:
- Gastric endoscopic submucosal dissection (ESD) can leave mucosal defects requiring effective closure.
- Optimized closure methods are needed to improve outcomes after gastric ESD.
Purpose of the Study:
- To develop and assess the feasibility and safety of a novel closure device, FLEXLOOP, for gastric mucosal defects post-ESD.
Main Methods:
- A multicenter, prospective, observational study involving 35 patients with gastric neoplasms < 30 mm.
- Closure of mucosal defects post-gastric ESD was performed using the FLEXLOOP device and standard clips.
- Primary outcome: complete closure rate; Secondary outcomes: procedure time, clip count, sustained closure, and post-ESD bleeding.
Main Results:
- Complete closure was achieved in 89% of patients (31/35).
- Median closure time was 11 minutes with a median of 10 clips used.
- No post-ESD bleeding or FLEXLOOP-related complications were observed.
Conclusions:
- FLEXLOOP closure is a feasible and safe technique for gastric mucosal defects post-ESD.
- This device presents a potentially simpler option for defect closure.
- Further clinical research is recommended to validate its efficacy in preventing delayed complications.
