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Updated: May 27, 2025

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management
Published on: March 15, 2024
Peripheral Nerve Stimulation for Chronic Foot Pain Induced by Morton Neuroma: A Novel, Personalized Approach in One
Brian Fabian Saway1, Reese Townsend Terry2, Aimee C Weber1
1Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Background And Importance:
Morton neuroma (MN) is a condition characterized by pain that is located within one or more intermetatarsal spaces of the forefoot. Numerous conservative measures are available for the management of mild-to-moderate MN cases. In more severe presentations, surgical interventions may be considered, including neuroma excision, cryogenic or radiofrequency ablation, and decompression. However, no standard treatments exist for occurrences of recurrent MN after surgery. Peripheral nerve stimulation is a neuromodulatory treatment that is highly effective for other neuropathic pain syndromes but remains underutilized for MN.
Clinical Presentation:
Here, we present the operative technique and clinical outcome in a patient with chronic pain induced by MN who underwent bilateral implantation of peripheral nerve stimulation devices. In less than 12 months, the patient had near-complete resolution of chronic foot pain with no postoperative complications.
Discussion:
We present the first published case and operative technique of successful peripheral nerve stimulator implantation as an effective treatment of MN.
Conclusion:
Peripheral nerve stimulator implantation is a promising and effective intervention that can be considered for refractory MN.

